The overall aim of EpiDOSE is to evaluate the effectiveness of a low cumulative dose of epinephrine compared to a standard cumulative dose of epinephrine on survival to hospital discharge following resuscitation from VF or pulseless VT in adults who experience an out-of-hospital cardiac arrest.
The study kit is comprised of the following:
We are collecting data from the Ambulance Call Report (ACR) combined with administrative databases such as the Discharge Abstract Database (DAD) and the National Ambulatory Care Reporting System Metadata (NACRS), if available. We will also be collecting information from survivor interviews.
Epinephrine for Out-of-Hospital Cardiac Arrest: A Systematic Review and Meta-Analysis Update.
Aves T, Chopra A, Patel M, Lin S. Crit Care Med. 2019.
The CJEM Debate Series: #Epi – There is no place for the use of intravenous epinephrine as a standard component of cardiac arrest resuscitation care.
Welsford M, Buick JE, Drennan IR, Lin S, Atkinson PR. CJEM. 2019;21(3):324-329.
Interpreting Observational Data on Adrenaline in Cardiac Arrest is Complicated.
Lin S, Dorian P. Resuscitation. 2019;138:314-315.
Study of the effects of epinephrine on cerebral oxygenation and metabolism during cardiac arrest and resuscitation by hyperspectral near-infrared spectroscopy.
Nosrati R, Lin S, Ramadeen A, Mohindra R, Toronov V, Dorian P. Crit Care Med. 2019;47(4):e349-e357.
Adrenaline for out-of-hospital cardiac arrest resuscitation: a systematic review and meta-analysis of randomised controlled trials.
Lin S, Callaway CW, Shah PS, Wagner JD, Beyene J, Ziegler CP, Morrison LJ. Resuscitation. 2014;85(6):732-40.
Wide variability in drug use in out-of-hospital cardiac arrest: a report from the resuscitation outcomes consortium.
Glover BM, Brown SP, Morrison L, et al. Resuscitation. 2012;83:1324-30.
