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  • Home
  • About Us
  • About EpiDOSE
    • Key Facts
  • For Patients & Families
    • Interview Questionnaires
  • For Investigators & EMS
  • Resources
  • Glossary
  • Contact

logologo

  • Home
  • About Us
  • About EpiDOSE
    • Key Facts
  • For Patients & Families
    • Interview Questionnaires
  • For Investigators & EMS
  • Resources
  • Glossary
  • Contact
  • Home
  • About Us
  • About EpiDOSE
    • Key Facts
  • For Patients & Families
    • Interview Questionnaires
  • For Investigators & EMS
  • Resources
  • Glossary
  • Contact

EpiDOSE: Key Facts

Who are we?

EpiDOSE is an acronym for the Epinephrine Dose: Optimal versus Standard Evaluation clinical trial.

It is a randomized controlled trial initiated by Dr. Paul Dorian and Dr. Steve Lin at St. Michael’s Hospital, in collaboration with physicians, paramedics, patients, families, and researchers. The study is funded by the Canadian Institutes of Health Research, Canada’s federal funding source for health research. Meet our team here

EpiDOSE

What is our goal?

The goal of EpiDOSE is to test how effective a lower total dose of epinephrine is compared to the current standard on survival in adults who experience an out-of-hospital cardiac arrest. The current usual dose (or standard dose) that most patients receive is 1mg of epinephrine every 3 to 5 minutes until return of spontaneous circulation or termination of resuscitation (unlimited total). The lower dose used in this study is up to 2mg total. Currently, the optimal total dose of epinephrine during an out-of-hospital cardiac arrest is unknown.

When will this study start?

Study enrollment will begin in 2022 and last for approximately 5 years.

Why are we doing this study?

The best total dose of epinephrine during an out-of-hospital cardiac arrest is unknown. Research has suggested that the standard total dose of epinephrine may be too high and that a lower dose strategy may be beneficial for long-term survival.

Where are we located?

Emergency medical services in British Columbia and Ontario, including Peel, Halton, Toronto, and Ottawa.

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EpiDOSE at St. Michael’s Hospital

30 Bond Street Toronto, ON, Canada M5B 1W8

Telephone: 416-864-6060

Email: epidose@unityhealth.to

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Our #Epi article was one the of 5 most downloaded Our #Epi article was one the of 5 most downloaded articles in the Canadian Journal of Emergency Medicine (CJEM) in 2019! 👏 #epidose #cjem
We’re blowing up on twitter! Make sure to follow We’re blowing up on twitter! Make sure to follow us if you haven’t done so already #EpiDOSE
Thank you to Professor Tom Quinn for his mention o Thank you to Professor Tom Quinn for his mention of #EpiDOSE in his presentation at the #ESCcongress #WCC2019 @europeansocietyofcardiology
Be sure to follow us on twitter for updates about Be sure to follow us on twitter for updates about the #epidose trial!
Heart attack vs. cardiac arrest. Know the differen Heart attack vs. cardiac arrest. Know the difference, it can save a life. #epidose
Wondering what sudden cardiac arrest is? Wonder no Wondering what sudden cardiac arrest is? Wonder no more. #epidose
Each year in Canada, there are over 40,000 people Each year in Canada, there are over 40,000 people who collapse from cardiac arrest. 8 in 10 cardiac arrests occur at home or in public places. However, only 1 in 10 survive cardiac arrests that happen outside of the hospital. #epidose
Hello and welcome to EpiDOSE 👋! The study that Hello and welcome to EpiDOSE 👋! The study that aims to evaluate optimal vs. standard doses of epinephrine in out of hospital cardiac arrest patients. Follow us along on our journey to make patient care better.
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