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  • About Us
  • About EpiDOSE
    • Key Facts
  • For Patients & Families
    • Interview Questionnaires
  • For Investigators & EMS
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logologo

  • Home
  • About Us
  • About EpiDOSE
    • Key Facts
  • For Patients & Families
    • Interview Questionnaires
  • For Investigators & EMS
  • Resources
  • Glossary
  • Contact
  • Home
  • About Us
  • About EpiDOSE
    • Key Facts
  • For Patients & Families
    • Interview Questionnaires
  • For Investigators & EMS
  • Resources
  • Glossary
  • Contact

About EpiDOSE

Cardiac Arrest is a life threatening event

Each year in Canada, there are over 30,000 people who collapse from cardiac arrest. Sudden cardiac arrest happens when the heart suddenly and unexpectedly stops beating, reducing blood flow to the brain and other vital organs.

This life threatening event is treated by paramedics with cardiopulmonary resuscitation (CPR), defibrillator shocks and drugs, including the routine use of epinephrine (adrenaline). Epinephrine can help reverse cardiac arrest by increasing blood flow to the heart and other organs. Paramedics in Canada give 1mg of epinephrine every 3 to 5 minutes which is the usual practice or ‘standard dose’. Although the standard dose of epinephrine can help restart the heart in the short-term, many patients do not survive due to irreversible brain injury and brain death.

Despite decades of use, there is limited proof that the standard dose of epinephrine is effective at improving long-term outcomes. There is some research to suggest that a lower dose of epinephrine may lead to better outcomes, but more studies are needed to determine this.

The objective

The objective of the EpiDOSE clinical trial is to test how effective a lower dose of epinephrine is (up to 2mg total) compared to the current standard dose of epinephrine (up to 6mg total) during CPR in adults who experience an out-of-hospital cardiac arrest. The study will involve Emergency Medical Service agencies in British Colombia, Ontario and Saskatchewan.
EpiDOSE will be the first clinical trial to test the effects of a low total dose of epinephrine compared to the current standard during cardiac arrest resuscitation. Results from this research may change cardiac arrest treatment in Canada and worldwide.

Study Participation

This trial includes adults, aged 18 years and older, who experience an out-of-hospital cardiac arrest from abnormal heart rhythms of ventricular fibrillation and pulseless ventricular tachycardia in areas serviced by participating Emergency Medical Service agencies.

If you or your loved one was enrolled in EpiDOSE visit here.

EpiDOSE at St. Michael’s Hospital

30 Bond Street Toronto, ON, Canada M5B 1W8

Telephone: 416-864-6060

Email: epidose@unityhealth.to

epidose_trial

Our #Epi article was one the of 5 most downloaded Our #Epi article was one the of 5 most downloaded articles in the Canadian Journal of Emergency Medicine (CJEM) in 2019! 👏 #epidose #cjem
We’re blowing up on twitter! Make sure to follow We’re blowing up on twitter! Make sure to follow us if you haven’t done so already #EpiDOSE
Thank you to Professor Tom Quinn for his mention o Thank you to Professor Tom Quinn for his mention of #EpiDOSE in his presentation at the #ESCcongress #WCC2019 @europeansocietyofcardiology
Be sure to follow us on twitter for updates about Be sure to follow us on twitter for updates about the #epidose trial!
Heart attack vs. cardiac arrest. Know the differen Heart attack vs. cardiac arrest. Know the difference, it can save a life. #epidose
Wondering what sudden cardiac arrest is? Wonder no Wondering what sudden cardiac arrest is? Wonder no more. #epidose
Each year in Canada, there are over 40,000 people Each year in Canada, there are over 40,000 people who collapse from cardiac arrest. 8 in 10 cardiac arrests occur at home or in public places. However, only 1 in 10 survive cardiac arrests that happen outside of the hospital. #epidose
Hello and welcome to EpiDOSE 👋! The study that Hello and welcome to EpiDOSE 👋! The study that aims to evaluate optimal vs. standard doses of epinephrine in out of hospital cardiac arrest patients. Follow us along on our journey to make patient care better.
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