The overall aim of EpiDOSE is to evaluate the effectiveness of a low cumulative dose of epinephrine compared to a standard cumulative dose of epinephrine on survival to hospital discharge following resuscitation from VF or pulseless VT in adults who experience an out-of-hospital cardiac arrest.
All patients arriving to Emergency Departments will arrive with:
All patients arriving to an Emergency Department in Ontario arrive with the following fact sheet, that gives additional information about EpiDOSE trial, and what this means for patients arriving to the ED.
All patients arriving to an Emergency Department in Ontario should also arrive with a Patient & Family notification letter. This letter informs patients that they have been enrolled in the study, tells them a bit about the study itself, and gives useful info on how to discover more at our website, as well as how to get in touch with a study team member if there are any issues or questions.
All patients arriving to an Emergency Department in Ontario will also arrive with an EpiDOSE wristband as an additional notification that they were enrolled in the study. Please leave this wristband on the patient, unless it interferes with clinical treatment.
Epinephrine for Out-of-Hospital Cardiac Arrest: A Systematic Review and Meta-Analysis Update.
Aves T, Chopra A, Patel M, Lin S. Crit Care Med. 2019.
The CJEM Debate Series: #Epi – There is no place for the use of intravenous epinephrine as a standard component of cardiac arrest resuscitation care.
Welsford M, Buick JE, Drennan IR, Lin S, Atkinson PR. CJEM. 2019;21(3):324-329.
Interpreting Observational Data on Adrenaline in Cardiac Arrest is Complicated.
Lin S, Dorian P. Resuscitation. 2019;138:314-315.
Study of the effects of epinephrine on cerebral oxygenation and metabolism during cardiac arrest and resuscitation by hyperspectral near-infrared spectroscopy.
Nosrati R, Lin S, Ramadeen A, Mohindra R, Toronov V, Dorian P. Crit Care Med. 2019;47(4):e349-e357.
Adrenaline for out-of-hospital cardiac arrest resuscitation: a systematic review and meta-analysis of randomised controlled trials.
Lin S, Callaway CW, Shah PS, Wagner JD, Beyene J, Ziegler CP, Morrison LJ. Resuscitation. 2014;85(6):732-40.
Wide variability in drug use in out-of-hospital cardiac arrest: a report from the resuscitation outcomes consortium.
Glover BM, Brown SP, Morrison L, et al. Resuscitation. 2012;83:1324-30.